Spontaneous and 5-azacytidine-induced reexpression of ornithine carbamoyl transferase in hepatoma cells.
Mol Cell Biol
; 4(4): 809-12, 1984 Apr.
Article
en En
| MEDLINE
| ID: mdl-6201723
ABSTRACT
Rat hepatoma cells that do not synthesize the hepatic enzyme ornithine carbamoyl transferase spontaneously give rise to producing cells at a low frequency. Reexpression of this differentiation trait is strongly increased by 5-azacytidine treatment, suggesting that hypermethylation plays a critical role in the impaired expression of the ornithine carbamoyl transferase gene in hepatoma cells.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ornitina Carbamoiltransferasa
/
Azacitidina
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Año:
1984
Tipo del documento:
Article