Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary.
Science
; 212(4500): 1279-81, 1981 Jun 12.
Article
en En
| MEDLINE
| ID: mdl-6262917
ABSTRACT
Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus. It has no effect on basal or stimulated growth hormone release from primary cultures of rat adenohypophyseal cells during a 4-hour incubation, but inhibits stimulated release by more that 90 percent after 24 hours. These findings suggest that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adenohipófisis
/
Somatomedinas
/
Hormona del Crecimiento
/
Hipotálamo
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1981
Tipo del documento:
Article