Enhanced production of hydroxyl radicals by the xanthine-xanthine oxidase reaction in the presence of lactoferrin.
Biochim Biophys Acta
; 715(1): 116-20, 1982 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-6280774
The generation of hydroxyl radicals by the xanthine-xanthine oxidase reaction (C. Beauchamp and I. Fridovich (1970) J. Biol. Chem. 245, 4641-1616) has been shown to be increased by iron-saturated lactoferrin isolated from pig neutrophils. Hydroxyl radical production, measured by EPR spin trapping and by ethylene production from alpha-keto-gamma-methiol butyric acid, has been demonstrated to be produced by a Fenton-type Haber-Weiss reaction catalysed by lactoferrin. The possibility that lactoferrin catalyses such a reaction in vivo is considered.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Xantina Oxidasa
/
Xantinas
/
Hidróxidos
/
Lactoferrina
/
Lactoglobulinas
Límite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1982
Tipo del documento:
Article