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Enhanced production of hydroxyl radicals by the xanthine-xanthine oxidase reaction in the presence of lactoferrin.
Biochim Biophys Acta ; 715(1): 116-20, 1982 Mar 15.
Article en En | MEDLINE | ID: mdl-6280774
The generation of hydroxyl radicals by the xanthine-xanthine oxidase reaction (C. Beauchamp and I. Fridovich (1970) J. Biol. Chem. 245, 4641-1616) has been shown to be increased by iron-saturated lactoferrin isolated from pig neutrophils. Hydroxyl radical production, measured by EPR spin trapping and by ethylene production from alpha-keto-gamma-methiol butyric acid, has been demonstrated to be produced by a Fenton-type Haber-Weiss reaction catalysed by lactoferrin. The possibility that lactoferrin catalyses such a reaction in vivo is considered.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Xantina Oxidasa / Xantinas / Hidróxidos / Lactoferrina / Lactoglobulinas Límite: Animals Idioma: En Revista: Biochim Biophys Acta Año: 1982 Tipo del documento: Article
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Xantina Oxidasa / Xantinas / Hidróxidos / Lactoferrina / Lactoglobulinas Límite: Animals Idioma: En Revista: Biochim Biophys Acta Año: 1982 Tipo del documento: Article