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The production of hydroxyl radicals by adriamycin in red blood cells.
FEBS Lett ; 157(1): 170-2, 1983 Jun 27.
Article en En | MEDLINE | ID: mdl-6305715
Spin trapping of the free radicals formed from the interaction between adriamycin and red blood cells resulted in the formation of a hydroxyl spin adduct. The formation of hydroxyl radicals was found to be inhibited by mannitol. Hemoglobin was found not to be obligatory for the formation of hydroxyl radicals which probably result from the reduction of hydrogen peroxide by adriamycin semiquinone.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Doxorrubicina / Eritrocitos / Hidróxidos Límite: Humans Idioma: En Revista: FEBS Lett Año: 1983 Tipo del documento: Article
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Doxorrubicina / Eritrocitos / Hidróxidos Límite: Humans Idioma: En Revista: FEBS Lett Año: 1983 Tipo del documento: Article