The production of hydroxyl radicals by adriamycin in red blood cells.
FEBS Lett
; 157(1): 170-2, 1983 Jun 27.
Article
en En
| MEDLINE
| ID: mdl-6305715
Spin trapping of the free radicals formed from the interaction between adriamycin and red blood cells resulted in the formation of a hydroxyl spin adduct. The formation of hydroxyl radicals was found to be inhibited by mannitol. Hemoglobin was found not to be obligatory for the formation of hydroxyl radicals which probably result from the reduction of hydrogen peroxide by adriamycin semiquinone.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Doxorrubicina
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Eritrocitos
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Hidróxidos
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1983
Tipo del documento:
Article