Effect of muscarinic ligands on the electrical activity recorded from the hippocampus: a quantitative approach.
Br J Pharmacol
; 82(2): 431-40, 1984 Jun.
Article
en En
| MEDLINE
| ID: mdl-6375796
ABSTRACT
The electrical activity of the hippocampus was recorded from the CA 1 region in rats anaesthetized with halothane and the effects of compounds assessed following their intravenous injection. Quantification of the effects was achieved following on-line fast Fourier transformation of the signal. The electrical activity recorded from the hippocampus of the halothane-anaesthetized rat demonstrated identical characteristics to that recorded from the freely-moving animal. Three types of activity could be distinguished rhythmical slow wave activity (RSA or theta); large amplitude slow wave activity (LIA); and small amplitude fast wave activity. Muscarinic agonists induced RSA with a consequent reduction in power. The effects were dose-dependent and were reversibly antagonized by scopolamine, but not methyl-scopolamine, indicating that the effects are mediated centrally by muscarinic receptors. The results show that, in halothane anaesthetized rats, a muscarinic RSA occurs which is unrelated to movement or behavioural arousal.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Parasimpaticomiméticos
/
Receptores Muscarínicos
/
Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Año:
1984
Tipo del documento:
Article