Immunochemical evidence for an additional H-2 region closely linked to H-2D.
J Exp Med
; 145(2): 438-42, 1977 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-64585
ABSTRACT
Anti-H-2 reagents have been tested on solubilized spleen cell preparations in combinations expected to be specific for D region products. Two different types of molecules were detected. One showed the expected reactivity with both antisera to private and antisera to public specificities. However, an additional molecule was detected which reacted only with antisera to public specificities. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis migration patterns indicated that both products have a similar molecular size of approximately 45,000 daltons. The data therefore present chemical evidence for the existence of a third H-2-associated gene product of 45,000 mol wt in addition to the classical H-2K and H-2D antigens.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genes
/
Antígenos de Histocompatibilidad
/
Ligamiento Genético
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1977
Tipo del documento:
Article