Endocrine effects of tamoxifen in postmenopausal breast cancer patients.
Tumori
; 70(1): 61-8, 1984 Feb 29.
Article
en En
| MEDLINE
| ID: mdl-6538707
ABSTRACT
The effects of tamoxifen on plasma concentration of gonadotropins, prolactin (PRL), estrone (E1), estradiol-17 beta (E2), and sex hormone-binding globulin (SHBG) were studied in 40 postmenopausal breast cancer patients. In addition, the changes induced by the drug on endometrium and vaginal epithelium were investigated. After 6-8 weeks of tamoxifen treatment, a significant decrease in FSH, LH and PRL basal levels was observed, whereas the concentrations of E1 and E2 were not significantly affected. A significant increase in SHBG levels was induced by prolonged treatment with the drug. In addition, tamoxifen caused a partial estrogenization of vaginal smears, and a weak stimulatory effect on endometrium was also apparent. These findings indicate that tamoxifen produced agonistic effects on some targets and antagonistic effects on the others.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tamoxifeno
/
Neoplasias de la Mama
/
Menopausia
/
Hormonas
Límite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Tumori
Año:
1984
Tipo del documento:
Article