The influence of early postnatal treatment with haloperidol on the effects induced by small and large doses of apomorphine on locomotion of adult rats.
Neuropharmacology
; 22(9): 1137-9, 1983 Sep.
Article
en En
| MEDLINE
| ID: mdl-6633823
ABSTRACT
Chronic administration of haloperidol (0.5 mg/kg, s.c.) during early postnatal life did not modify the effects produced by a small dose of apomorphine (0.02 mg/kg, s.c.) on the locomotor activity of adult rats; conversely, the reduction of locomotion induced by a large dose of apomorphine (1 mg/kg, s.c.) was much more kared in haloperidol-pretreated rat than in saline-pretreated ones. The differential ontogeny of dopamine auto- and postsynaptic receptors could be partly responsible for the different influence of postnatal treatment with haloperidol on the responsiveness of the adult to small and large doses of apomorphine.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Apomorfina
/
Haloperidol
/
Actividad Motora
Límite:
Animals
Idioma:
En
Revista:
Neuropharmacology
Año:
1983
Tipo del documento:
Article