Effects of calcium and neomycin on phase behavior of phospholipid bilayers.
J Pharm Sci
; 72(12): 1465-7, 1983 Dec.
Article
en En
| MEDLINE
| ID: mdl-6663487
ABSTRACT
Calcium ion (Ca2+, 5 mM) caused a large upward shift in the transition temperature (Tc) of dipalmitoyl phosphatidylglycerol liposomes, apparently interacting with external and internal lipid in the bilayer. Neomycin (1 mM) caused only a small shift, apparently not penetrating the internal lipid domains. When liposomes were first incubated with Ca2+ followed by neomycin, the shift in Tc indicated displacement of Ca2+ by the drug. Liposomes of dipalmitoyl phosphatidylcholine or distearoyl phosphatidylcholine did not interact significantly with either cation. In mixed dipalmitoyl phosphatidylcholine-dipalmitoyl phosphatidylglycerol and distearoyl phosphatidylcholine-dipalmitoyl phosphatidylglycerol liposomes, addition of Ca2+ or neomycin resulted in phase separation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfolípidos
/
Neomicina
/
Calcio
/
Liposomas
Idioma:
En
Revista:
J Pharm Sci
Año:
1983
Tipo del documento:
Article