The effect of topical 0.5% triamterene suspension on the intraocular pressure of open angle glaucoma patients. A single dose study.

ABSTRACT

The effect of a topical 0.5% triamterene suspension on the intra-ocular pressure of 15 open angle glaucoma patients was investigated. On the first day measurements were made at 09.00, 12.00 and 16.30 hours without treatment. On the second day measurements were made at 09.00 hours and 1, 2, 4 and 6 hours following instillation of the suspension into the eye. Without treatment there were no significant changes in intra-ocular pressure. After topical triamterene the maximum group mean pressure reduction was -4.7 mm Hg at 6 hours and mean intra-ocular pressures were less than 22 mm Hg at both 4 and 6 hours. There was also a notable decrease in intra-ocular pressure in two thirds of the contralateral untreated eyes which was not attributable to diurnal variation. No local or systemic side effects were observed.