Effects of atropine on respiratory heat loss in asthma.
J Appl Physiol Respir Environ Exerc Physiol
; 48(4): 619-23, 1980 Apr.
Article
en En
| MEDLINE
| ID: mdl-6769881
ABSTRACT
We have previously observed that although atropine does not alter the magnitude of the response to exercise while breathing cold air, it does cause the predominant site of obstruction to move into the lung periphery. To determine if this effect was due to changes in the conditioning of inspired air, we measured respiratory heat loss (RHL) and retrotracheal (Trt) and retrocardiac esophageal temperature in eight asthmatics while they performed eucapnic hyperventilation with cold air before and after the inhalation of atropine. Multiple aspects of pulmonary mechanics were also recorded. Significant and equivalent airway obstruction developed with and without atropine (control delta FEV1 = 1.0 +/- 0.2 (SE) liter; postatropine = 0.9 +/- 0.3 liter). Despite this, RHL was 17.1% greater and Trt fell 16% more after atropine. These data demonstrate that atropine can influence heat transfer within the lung and alter the sites of conditioning.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Atropina
/
Regulación de la Temperatura Corporal
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Appl Physiol Respir Environ Exerc Physiol
Año:
1980
Tipo del documento:
Article