Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities.
Psychopharmacology (Berl)
; 68(2): 155-8, 1980.
Article
en En
| MEDLINE
| ID: mdl-6776558
ABSTRACT
A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r = -0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Prejuicio
/
Receptores de Serotonina
/
Alucinógenos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
1980
Tipo del documento:
Article