Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in making inferences about the mechanism of resistance and the structure of the enzyme is situ compared with the enzyme in vitro.
J Med Chem
; 24(12): 1422-9, 1981 Dec.
Article
en En
| MEDLINE
| ID: mdl-6796688
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Triazinas
/
Antagonistas del Ácido Fólico
/
Lacticaseibacillus casei
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1981
Tipo del documento:
Article