[Effects of the contamination by polychlorobiphenyls (PCBs) on the growth of the Ehrlich tumor in mice (author's transl)]. / Effets de la contamination par les polychlorobiphényles (PCB) sur le développement de la tumeur d'Ehrlich chez la souris Swiss.
Toxicol Eur Res
; 3(5): 229-36, 1981 Sep.
Article
en Fr
| MEDLINE
| ID: mdl-6803399
ABSTRACT
The effects of a 3-month experimental contamination with a commercial mixture of PCBs, DP5 (corresponding to Aroclor 1254) have been studied on groups of 25 SWISS female mice, at levels of 0, 10, 50 and 250 ppm added at feeding. After subcutaneous injection of 0,2 ml of Ehrlich's tumoral ascites liquid, the evolution of tumors as well as the mortality level, were different in the treated groups as compared to the control group. The percentages of mortality due to tumors were the following control (0 ppm) = 50% 10 ppm = 5% 50 ppm = 5% 250 ppm = 35% Thus, contamination by PCBs seems to have protected these mice against the Ehrlich tumor. No decrease in body weight was noted neither were differences in size or appearance of the thymus and the spleen in the treated mice; an evident liver hypertrophy was noted in all PCB treated mice.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Ehrlich
/
Contaminación de Alimentos
/
Bifenilos Policlorados
Límite:
Animals
Idioma:
Fr
Revista:
Toxicol Eur Res
Año:
1981
Tipo del documento:
Article