The metabolism of 125I-labelled insulin by isolated Zucker rat hepatocytes.
Biosci Rep
; 1(12): 903-10, 1981 Dec.
Article
en En
| MEDLINE
| ID: mdl-7032619
ABSTRACT
The metabolism of 125I-labelled insulin by hepatocytes isolated from 48-h-starved Zucker lean and obese rats was studied. Hepatocytes from the lean animals bound significantly more 125I-labelled insulin and had a greater receptor number per cell than did cells from obese littermates. Hepatocytes from the lean animals degraded and internalized more hormone than did those from obese ones. Increased degradation and internalization correlated with the increased receptor number.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ratas Mutantes
/
Ratas Zucker
/
Insulina
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Biosci Rep
Año:
1981
Tipo del documento:
Article