Preliminary studies on the absorption, distribution and excretion of 2-(7'theophyllinemethyl)-1,3-dioxolane in the rat.
Farmaco Sci
; 36(3): 220-4, 1981 Mar.
Article
en En
| MEDLINE
| ID: mdl-7227505
ABSTRACT
Preliminary studies in the rat were carried out on the absorption, distribution and excretion of 2-(7'-theophyllinemethyl)-1,3-dioxolane (ABC 12/3), a new compound with anti-bronchospastic activity. Our results show that ABC 12/3 is rapidly absorbed and remains in the blood for about 6 hours. The distribution of this compound in the various tissues appears quite rapid, reaching good concentrations in the lung. Urinary excretion is complete within 12 hours after the administration of the compound, which is metabolized like a theophylline derivative.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Teofilina
Límite:
Animals
Idioma:
En
Revista:
Farmaco Sci
Año:
1981
Tipo del documento:
Article