Antiallergic activity of tetracyclic derivatives of quinoline-2-carboxylic acids. 1.
J Med Chem
; 21(9): 984-8, 1978 Sep.
Article
en En
| MEDLINE
| ID: mdl-722763
ABSTRACT
Substitution of 1,4-dihydro-4-oxoquinoline-2-carboxylic acid by acetyl, benzoyl, and phenylsulfonyl substituents was found to enhance activity in the rat passive cutaneous anaphylaxis assay. A further increase in activity, to equipotency with DSCG, was achieved by incorporation of the 8-benzoyl moiety into a tetracyclic structure to give 1,4-dihydro-4,11(1H,11H)-dioxoindeno[1,2-h]quinoline-2-carboxylic acid (20). In contrast, the reverse isomer 19 was found to have little activity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Anafilaxis Cutánea Pasiva
Límite:
Animals
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1978
Tipo del documento:
Article