The effects of horseradish peroxidase on the concentration of 5-hydroxytryptamine and platelet counts in blood of rabbits and guinea pigs.

ABSTRACT

When HRP was injected i.v. in rabbits and guinea pigs, a rapid fall in the number of circulating platelets and the concentration of 5 HT occurred. Platelet aggregates were trapped in lung capillaries. The aggregation was reversible and the return of platelets to the circulation concomitant with a rise in blood 5 HT concentration.