Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.

Nakayama, C; Wataya, Y; Meyer, R B; Santi, D V; Saneyoshi, M; Ueda, T

Nakayama, C; Wataya, Y; Meyer, R B; Santi, D V; Saneyoshi, M; Ueda, T.

J Med Chem ; 23(8): 962-4, 1980 Aug.

Article en En | MEDLINE | ID: mdl-7401121

RESUMEN

A continuous spectrophotometric assay for thymidine phosphorylase has been developed and used to analyze the substrate properties of a number of 5-substituted 2'-deoxyuridines. A QSAR was found which relates the catalytic efficiency for various substrates to a single variable, the inductive field constant F.

Asunto(s)

Desoxiuridina/análogos & derivados; Pentosiltransferasa/metabolismo; Timidina Fosforilasa/metabolismo; Animales; Desoxiuridina/metabolismo; Caballos; Técnicas In Vitro; Modelos Biológicos; Espectrofotometría Ultravioleta; Relación Estructura-Actividad; Especificidad por Sustrato

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pentosiltransferasa / Timidina Fosforilasa / Desoxiuridina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 1980 Tipo del documento: Article

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