Aza-tricyclic substance P antagonists.
J Med Chem
; 37(18): 2831-40, 1994 Sep 02.
Article
en En
| MEDLINE
| ID: mdl-7520943
ABSTRACT
The synthesis and structure-activity relationships of a series of aza-tricyclic analogs of the quinuclidine substance P (SP) antagonist 1 are described. The SP receptor affinity of these compounds was found to vary according to the size of the new ring fused to the quinuclidine and the mode of fusion. Correlations between receptor affinity and (1) the steric bulk of the newly introduced ring fusion and (2) the dihedral angle between the benzhydryl and benzylamino substituents of these aza-tricyclic compounds were explored.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hidrocarburos Aromáticos con Puentes
/
Sustancia P
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1994
Tipo del documento:
Article