Structure of the new spiroketal-macrolide A82548A.
J Antibiot (Tokyo)
; 48(9): 990-6, 1995 Sep.
Article
en En
| MEDLINE
| ID: mdl-7592067
A new member of the spiroketal-containing macrolide class of fermentation-derived natural products was isolated from mycelial extracts of Streptomyces diastatochromogenes. The principal component, A82548A, was shown to possess a 22-membered macrolide ring system onto which was incorporated both a spiroketal and a hemiketal moiety. Relative stereochemistry was established by single crystal X-ray diffraction studies. Absolute stereochemistry was determined via hydrolysis of the amino sugar glycosidically linked to the aglycone, which was identified as L-kedarosamine. The overall three-dimensional structure is closely related to that of the macrolides cytovaricin, rutamycin, and ossamycin.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos