Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma.
Atherosclerosis
; 114(1): 45-54, 1995 Apr 07.
Article
en En
| MEDLINE
| ID: mdl-7605375
ABSTRACT
Sections of human atherosclerotic lesions of different stages show that, in early lesions, the acellular lipid core is usually immediately adjacent to the deepest edge of a collection of macrophage foam cells. Advanced lesions with a large lipid core have variable numbers of macrophage foam cells, close to the lateral edges, or shoulders, of the core. In both early and advanced lesions, some of the macrophages nearest the core appear to be dying. Lipid cores contain two materials which in earlier lesions are found only in macrophages, namely ceroid and CD68 antigen, but do not contain recognisable smooth muscle cell actin. It is concluded that death of macrophage foam cells contributes to the origin and slow enlargement of the lipid core. The cause of macrophage death is not yet certain, but is under investigation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Arteriosclerosis
/
Metabolismo de los Lípidos
/
Células Espumosas
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Atherosclerosis
Año:
1995
Tipo del documento:
Article
País de afiliación:
Reino Unido