Immunological and clinical response to immunosuppressive treatment in paraneoplastic cerebellar degeneration.
Arch Neurol
; 52(8): 814-8, 1995 Aug.
Article
en En
| MEDLINE
| ID: mdl-7639633
ABSTRACT
OBJECTIVE:
To report the clinical and immunological response to immunosuppressive treatment with cyclophosphamide in two patients with paraneoplastic cerebellar degeneration.DESIGN:
Case reports. Clinical and immunological follow-up data available for 4 1/2 years in the first patient and for 2 years in the second patient.SETTING:
A 1500-bed university hospital and a 1200-bed university teaching hospital. INTERVENTION Cyclophosphamide intermittent treatment. MAIN OUTCOMEMEASURE:
Clinical disability.RESULTS:
One of the patients, who was treated from an early stage, recovered completely. The other patient showed a partial clinical response. While the two patients were receiving a maintenance regimen with cyclophosphamide, the conditions of both patients remained stable for at least 2 years. In both patients, intrathecal antibody synthesis declined considerably.CONCLUSION:
Early induction of immunosuppressive therapy with cyclophosphamide should be tried in treating patients with paraneoplastic cerebellar degeneration.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndromes Paraneoplásicos
/
Enfermedades Cerebelosas
/
Ciclosporina
/
Ciclofosfamida
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Arch Neurol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Alemania