Microsatellite evolution--evidence for directionality and variation in rate between species.
Nat Genet
; 10(3): 337-43, 1995 Jul.
Article
en En
| MEDLINE
| ID: mdl-7670473
ABSTRACT
Microsatellite DNA sequences are rapidly becoming the dominant source of nuclear genetic markers for a wide range of applications, from genome mapping to forensic testing to population studies. If misinterpretation is to be avoided, it is vital that we understand fully the way in which microsatellite sequences evolve. We have therefore compared allele length distributions for 42 microsatellites in humans with their homologues in a range of related primates. We find a highly significant trend for the loci to be longer in humans, showing that microsatellites can evolve directionally and at different rates in closely related species.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ADN Satélite
/
Evolución Biológica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Reino Unido