Samarium-153-EDTMP biodistribution and dosimetry estimation.
J Nucl Med
; 34(7): 1031-6, 1993 Jul.
Article
en En
| MEDLINE
| ID: mdl-7686217
ABSTRACT
Fifty-two patients were treated with single doses of 153Sm-EDTMP in a Phase I escalating dose protocol for palliation of bone pain from metastatic prostate carcinoma. Samarium-153 (T1/2 46.3 hr), maximum beta-particle energies 810 keV (20%), 710 keV (30%), 640 keV (50%), gamma photon 103 keV (28%), was complexed to the tetraphosphonate chelate, EDTMP. Five groups of patients were treated at doses of 1.0, 1.5, 2.0, 2.5, and 3.0 mCi/kg to evaluate toxicity from treatment. Patients were screened prior to treatment and followed after treatment with 99mTc-MDP bone scans. Biodistribution data on this group of patients were acquired and showed rapid uptake of 153Sm-EDTMP into bone with complete clearance of nonskeletal radiotoxicity by 6-8 hr. Also included are complete sets of dosimetry estimations on an additional seven patients who received 0.5 mCi/kg 153Sm-EDTMP Ca++ as part of a multiple dose therapy trial. Estimated radiation absorbed doses to bone surfaces averaged 25,000 mrad/mCi (6686 Gy/MBq), and urinary bladder doses averaged 3600 mrad/mCi (964 Gy/MBq).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
Compuestos Organofosforados
/
Cuidados Paliativos
/
Neoplasias de la Próstata
/
Radioisótopos
/
Samario
/
Neoplasias Óseas
/
Quelantes
Tipo de estudio:
Guideline
Límite:
Humans
/
Male
Idioma:
En
Revista:
J Nucl Med
Año:
1993
Tipo del documento:
Article