Over-expression of the MDM2 gene is found in some cases of haematological malignancies.
Br J Haematol
; 88(2): 415-8, 1994 Oct.
Article
en En
| MEDLINE
| ID: mdl-7803295
ABSTRACT
We looked for MDM2 gene amplification and over-expression by Southern and Northern blot analysis in 135 and 66 cases of haematological malignancies, including ALL, AML, CML in chronic phase, CLL, MDS, PLL, non-Hodgkin's lymphoma (NHL) and myeloma. No amplification of the gene was found. An over-expression of MDM2 RNA was seen in 9/66 (14%) patients tested, including 3/9 ALL, 3/24 AML, 2/4 myelomas, 1/1 PLL, but 0/2 CML, 0/2 NHL and 0/21 MDS. None of the patients over-expressing MDM2 had modifications of P53 gene transcript or p53 mutations. Most of the patients over-expressing MDM2 gene had poor prognostic features (including 'unfavourable' cytogenetic abnormalities), poor response to chemotherapy and short survival. Our findings suggest that over-expression of MDM2 is seen in a relatively small number of haematological malignancies, and is associated with poor prognosis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Leucemia
/
Proteínas Proto-Oncogénicas
/
Mieloma Múltiple
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Br J Haematol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Francia