Acyclovir-resistant, pathogenic herpesviruses.
Trends Microbiol
; 2(12): 481-5, 1994 Dec.
Article
en En
| MEDLINE
| ID: mdl-7889324
ABSTRACT
In herpes simplex virus, the simplest path to resistance to the drug acyclovir is a mutation that knocks out the enzyme thymidine kinase. Such mutants are highly attenuated in mouse models of viral pathogenesis, but have been reported to be associated with severe disease in immunocompromised patients. This review discusses possible resolution of this paradox.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timidina Quinasa
/
Aciclovir
/
Simplexvirus
/
Herpes Simple
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
1994
Tipo del documento:
Article