Detection of human cytomegalovirus genome in uterus tissue.
Arch Virol
; 135(3-4): 265-77, 1994.
Article
en En
| MEDLINE
| ID: mdl-7979967
ABSTRACT
To analyze persistent infection by human cytomegalovirus (HCMV) in vivo, specimens obtained from various sources and autopsied organs were examined for the presence of HCMV DNA, mRNA transcripts and antigens by polymerase chain reaction, in situ hybridization and immunostaining. The HCMV genome was detected in lung, liver, kidney, and blood vessels at an average positive rate of 15%. The highest PCR-positive rate was observed with cervical smears. Subsequent examination of uterus tissues from patients with myoma revealed HCMV transcripts and antigens in glandular epithelial cells, leukocytes, endothelial cells, and others, indicating productive HCMV infection of cervical tissue.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Útero
/
Genoma Viral
/
Citomegalovirus
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
Arch Virol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón