Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein.
Br J Pharmacol
; 111(4): 978-80, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8032624
ABSTRACT
The effect of diosmin, a flavone derivative, on the Ca2+ sensitivity of the venous contractile apparatus was investigated in chemically (beta-escin) skinned strips from the rat isolated femoral vein. Diosmin (0.5-10 microM) shifted to the left the concentration-response curve to Ca2+ (0.05-5 microM). The maximal effect was observed in the presence of 1 microM diosmin which increased the contractile response evoked by 0.15 microM Ca2+ from 26.3% to 78.9% of the maximal Ca(2+)-induced response. This work demonstrates that the venotonic action of diosmin involves an increase in the Ca2+ sensitivity of the contractile apparatus. Such a mechanism of action could represent a new and important means of therapeutic control of vasomotor activity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vasoconstricción
/
Calcio
/
Diosmina
/
Músculo Liso Vascular
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Francia