Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas.
Nat Genet
; 4(2): 191-4, 1993 Jun.
Article
en En
| MEDLINE
| ID: mdl-8102299
ABSTRACT
Genomic imprinting plays a role in influencing the parental origin of genes involved in cancer-specific rearrangements. We have analysed 22 neuroblastomas with N-myc amplification to determine the parental origin of the amplified N-myc allele and the allele that is deleted from chromosome 1p. We analysed DNA from neuroblastoma patients and their parents, using four polymorphisms for 1p and three for the N-myc amplicon. We determined that the paternal allele of N-myc was preferentially amplified (12 out of 13 cases; P = 0.002). However, the paternal allele was lost from 1p in six out of ten cases, consistent with a random distribution (P > 0.2). These results suggest that parental imprinting influences which N-myc allele is amplified in neuroblastomas, but it does not appear to affect the 1p allele that is deleted in the cases that we have examined.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo de Longitud del Fragmento de Restricción
/
Regulación Neoplásica de la Expresión Génica
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Amplificación de Genes
/
Genes myc
/
Alelos
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Neuroblastoma
Límite:
Adult
/
Animals
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
1993
Tipo del documento:
Article