Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells.
Science
; 264(5164): 1467-71, 1994 Jun 03.
Article
en En
| MEDLINE
| ID: mdl-8197461
ABSTRACT
The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to re-enter the cell cycle. Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Proteínas
/
Proteína de Retinoblastoma
/
Músculos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1994
Tipo del documento:
Article