Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus.
Cancer Res
; 53(21): 5328-33, 1993 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-8221669
ABSTRACT
Renal allograft recipients are at greatly increased risk of developing squamous cell carcinomas. As these frequently arise adjacent to areas of multiple viral warts, we have investigated a possible role for human papillomavirus in malignant transformation within this population. We established, as primary cultures, keratinocytes from 24 lesions of varying degrees of squamous atypia from 9 patients. Ten of 14 cultures screened for the presence of episomal human papillomavirus DNA were positive using a mixed probe for cutaneous human papillomaviruses, although episomal copy was universally lost with continued passage. Three cultures, 2 of which were derived from malignant tissue and 1 from a benign lesion, were positive when screened with a probe for potentially oncogenic human papillomavirus DNAs 5 or 8. Both positive cultures of malignant origin exhibited extended lifespan and have been briefly characterized by morphology and growth requirements.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Complicaciones Posoperatorias
/
Piel
/
Neoplasias Cutáneas
/
Infecciones Tumorales por Virus
/
Transformación Celular Neoplásica
/
Trasplante de Riñón
/
Infecciones por Papillomavirus
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
1993
Tipo del documento:
Article
País de afiliación:
Reino Unido