Haptoglobin polymorphism and the immune response after hepatitis B vaccination.
Vaccine
; 11(12): 1188-90, 1993 Sep.
Article
en En
| MEDLINE
| ID: mdl-8256500
ABSTRACT
One hundred healthy Caucasian medical students (age 22 +/- 1 years) were vaccinated with a recombinant hepatitis B vaccine and their haptoglobin types were determined. A relationship between haptoglobin type and immune response to the vaccine was observed. Subjects with a 2-2 haptoglobin phenotype produced significantly lower hepatitis B antibody titres than those having a 1-1 or 2-1 haptoglobin phenotype. The haptoglobin phenotypes not only influenced the magnitude but also the kinetics of the anti-HBs response. For all haptoglobin types, haptoglobin concentration and immune response to the vaccine behaved independently.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Haptoglobinas
/
Vacunación
/
Vacunas contra Hepatitis B
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Vaccine
Año:
1993
Tipo del documento:
Article
País de afiliación:
Bélgica