A protein histidine kinase induced in rat liver by peroxisome proliferators. In vitro activation by Ras protein and guanine nucleotides.
FEBS Lett
; 319(1-2): 75-9, 1993 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-8454063
ABSTRACT
A novel protein kinase is induced in rat liver plasma membrane by the administration of peroxisome proliferators. A 36 kDa protein (P36) on the membrane was rapidly phosphorylated in vitro by the kinase and the phosphorylated amino acid was identified as phosphohistidine. Histidine phosphorylation of P36 was activated in vitro by recombinant Ras protein and GTP; both decreased Michaelis constant (Km) for ATP from 1.25 to 0.25 microM. The novel histidine kinase, products of which have been overlooked due to their acid lability, may participate in cellular signaling and peroxisome proliferators may perturb the pathway.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas
/
Proteínas Proto-Oncogénicas p21(ras)
/
Nucleótidos de Guanina
/
Hígado
/
Microcuerpos
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1993
Tipo del documento:
Article
País de afiliación:
Japón