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Immunohistochemical localization of parathyroid hormone-related protein in human prostate cancer.
Iwamura, M; di Sant'Agnese, P A; Wu, G; Benning, C M; Cockett, A T; Deftos, L J; Abrahamsson, P A.
Afiliación
  • Iwamura M; Department of Urology, University of Rochester School of Medicine, New York 14642-8656.
Cancer Res ; 53(8): 1724-6, 1993 Apr 15.
Article en En | MEDLINE | ID: mdl-8467485
Parathyroid hormone-related protein (PTHrP) is produced by a variety of malignant tumors and has been implicated as a major cause of humoral hypercalcemia of malignancy. Expression of PTHrP in prostate cancer tissue was studied immunohistochemically using 33 radical prostatectomy specimens from patients with clinically localized carcinoma of the prostate. None of these patients demonstrated hypercalcemia prior to the surgery. Acetone-methyl benzoate-xylene-processed, paraffin-embedded tissues were stained with a validated mouse monoclonal antibody to an amino acid fragment, PTHrP(109-141), using the streptavidin-peroxidase enzyme conjugate method. All cases (33 of 33; 100%) studied demonstrated some degree of immunoreactivity throughout the cytoplasm of the tumor cells, but immunostaining was absent from inflammatory and stromal cells. The intensity of the staining appeared to directly correlate with increasing tumor grade. The widespread immunohistochemical localization of PTHrP in carcinoma of the prostate suggests that PTHrP may play some local role in the growth of transformed cells in the prostate. Furthermore, overexpression of PTHrP may be a possible marker to evaluate the malignant potential of carcinoma of the prostate.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Proteínas / Proteínas de Neoplasias Límite: Aged / Animals / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Año: 1993 Tipo del documento: Article
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Proteínas / Proteínas de Neoplasias Límite: Aged / Animals / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Año: 1993 Tipo del documento: Article