Proliferation of human smooth muscle cells promoted by lipoprotein(a).
Science
; 260(5114): 1655-8, 1993 Jun 11.
Article
en En
| MEDLINE
| ID: mdl-8503012
ABSTRACT
Elevated blood concentrations of lipoprotein(a) [Lp(a)] and its constituent, apolipoprotein(a) [apo(a)], constitute a major risk factor for atherosclerosis, but their physiological activities remain obscure. Lp(a) and purified apo(a) stimulated the growth of human smooth muscle cells in culture. This effect resulted from inhibition of plasminogen activation, and consequently the activation by plasmin of latent transforming growth factor-beta, which is an inhibitor of smooth muscle cell growth. Because smooth muscle proliferation is one of the hallmarks of atherosclerotic lesions, these results point to a plausible mechanism for the atherogenic activity of Lp(a).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lipoproteína(a)
/
Músculo Liso Vascular
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1993
Tipo del documento:
Article
País de afiliación:
Reino Unido