Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.
Nat Genet
; 12(1): 31-7, 1996 Jan.
Article
en En
| MEDLINE
| ID: mdl-8528247
ABSTRACT
Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ratas Mutantes
/
Diabetes Mellitus Tipo 2
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Suecia