Liposomal muramyl tripeptide upregulates adhesion molecules on the surface of human monocytes.
Oncol Res
; 7(5): 253-7, 1995.
Article
en En
| MEDLINE
| ID: mdl-8534931
ABSTRACT
We previously demonstrated that liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE), a biologic response modifier now undergoing phase III clinical trial in osteosarcoma, upregulated monocyte expression of several cytokines' mRNA and the subsequent production of these proteins. In the present work, we investigated whether L-MTP-PE upregulated adhesion molecules on the surface of normal human monocytes. Flow-cytometric analysis showed that several subunits of the integrins, including alpha L, alpha 5, and beta 1 subunits, and intercellular adhesion molecule-1 on the monocytes were upregulated following their stimulation with 2 micrograms/ml L-MTP-PE for 24 h. Anti-alpha L antibodies blocked monocyte-mediated tumor cell killing stimulated by L-MTP-PE. We conclude that L-MTP-PE also stimulates the increase of several molecules on the monocyte cell surface. These adhesion molecules may contribute to the increased activation of monocyte-mediated tumor cell killing seen following L-MTP-PE exposure.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfatidiletanolaminas
/
Monocitos
/
Moléculas de Adhesión Celular
/
Acetilmuramil-Alanil-Isoglutamina
/
Factores Inmunológicos
Límite:
Humans
Idioma:
En
Revista:
Oncol Res
Asunto de la revista:
NEOPLASIAS
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos