The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination.
Mamm Genome
; 6(9): 636-9, 1995 Sep.
Article
en En
| MEDLINE
| ID: mdl-8535072
ABSTRACT
The melanocyte-stimulating hormone (MSH) receptor has a major function in the regulation of black (eumelanin) versus red (phaeomelanin) pigment synthesis within melanocytes. We report three alleles of the MSH-receptor gene found in cattle. A point mutation in the dominant allele ED gives black coat color, whereas a frameshift mutation, producing a prematurely terminated receptor, in homozygous e/e animals, produces red coat color. The wild-type allele E+ produces a variety of colors, reflecting the possibilities for regulating the normal receptor. Microsatellite analysis, RFLP studies, and coat color information were used to localize the MSH-receptor to bovine Chromosome (Chr) 18.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de la Hormona Hipofisaria
/
Color del Cabello
Límite:
Animals
Idioma:
En
Revista:
Mamm Genome
Asunto de la revista:
GENETICA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Noruega