Chronic haloperidol potentiates stimulated glutamate release in caudate putamen, but not prefrontal cortex.
Neuroreport
; 6(13): 1795-8, 1995 Sep 11.
Article
en En
| MEDLINE
| ID: mdl-8541484
ABSTRACT
Rats were given haloperidol continuously for 6 months via subcutaneous implants. Extracellular concentrations of basal and high K(+)-stimulated GABA and glutamate in the lateral caudate putamen and the medial prefrontal cortex were then assessed using microdialysis. While there were no significant differences in basal extracellular concentrations in either brain region, chronic haloperidol-treated rats showed significantly greater increases in glutamate following stimulation with high K+ in the caudate putamen, but not the prefrontal cortex. This effect was accompanied by an attenuation of K(+)-stimulated GABA overflow in the caudate putamen. These results suggest regionally selective alterations in amino acid transmitter function which may be related to chronic neuroleptic-induced motor side effects.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Putamen
/
Antipsicóticos
/
Núcleo Caudado
/
Corteza Prefrontal
/
Ácido Glutámico
/
Haloperidol
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos