Nicotine reinforcement in rats with histories of cocaine self-administration.
Psychopharmacology (Berl)
; 121(2): 282-3, 1995 Sep.
Article
en En
| MEDLINE
| ID: mdl-8545535
ABSTRACT
Few reports have described conditions under which nicotine self-administration occurs in rats. In this study, rats which initially lever pressed for cocaine infusion (0.05 mg/kg) during 1 h experimental sessions continued to obtain similar infusion numbers when nicotine (0.03 mg/kg) was available. When saline was substituted for nicotine, infusions decreased from 11.8 +/- 4.5/h to 5.4 +/- 1.1/h but returned to pre-saline levels when it was reintroduced (12.0 +/- 5.4/h). These results indicate that nicotine can serve as a positive reinforcer for rats under the historical and schedule conditions described.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Refuerzo en Psicología
/
Cocaína
/
Nicotina
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia