Genes encoding the beta 1 subunit of voltage-dependent Na+ channel in rat, mouse and human contain conserved introns.
FEBS Lett
; 377(3): 485-8, 1995 Dec 27.
Article
en En
| MEDLINE
| ID: mdl-8549781
ABSTRACT
We provide evidence in this study that the 86-bp insert in the beta 1.2 mRNA isoform of the voltage gated sodium channel is an intron. Transcripts still retaining this intron were detected in all tissues where the beta 1 gene expression was investigated. We also show that the exon/intron boundaries of the last two introns are conserved among rat, mouse and human beta 1 gene. Unlike the highly conserved cDNAs, introns in only the rat and mouse genes are highly related. The last intron is very short (86-90 bp) and is located in the 3' untranslated sequence, both uncommon properties of mammalian pre-mRNA introns.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Intrones
/
Canales de Sodio
/
Empalme del ARN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos