A recombinant fowlpox virus expressing the envelope antigen of subgroup A avian leukosis/sarcoma virus.
Avian Dis
; 39(3): 514-20, 1995.
Article
en En
| MEDLINE
| ID: mdl-8561735
ABSTRACT
A recombinant fowlpox virus (FPV) was constructed by inserting cloned sequences from Schmidt-Ruppin subgroup A avian sarcoma virus coding for the viral envelope (env) antigen into a nonessential region of FPV DNA downstream from a synthetic promoter. Sera from chickens hyperimmunized with the recombinant FPV neutralized the infectivity of the homologous subgroup A virus (RCASBP/AP) but only weakly neutralized the infectivity of Rous sarcoma virus, another subgroup A avian leukosis virus. Similarly, vaccination of 1-day-old chicks with this recombinant FPV protected against infection with RCASBP/AP virus but not against infection with another subgroup A Rous-associated virus (RAV-1). These results show that such a recombinant FPV can be used to protect chickens against avian leukosis virus and confirm previous observations that a type-specific antigenic variability existed within the subgroup A avian leukosis/sarcoma virus group.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas del Envoltorio Viral
/
Alpharetrovirus
/
Virus de la Viruela de las Aves de Corral
/
Vectores Genéticos
/
Antígenos Virales
Límite:
Animals
Idioma:
En
Revista:
Avian Dis
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos