Stimulation of the secretion of dehydroepiandrosterone by melatonin in mouse adrenals in vitro.
Life Sci
; 58(14): PL263-7, 1996.
Article
en En
| MEDLINE
| ID: mdl-8614260
ABSTRACT
Adrenals of young adult male mice kept on a LD 1212 lighting regimen for three weeks prior to study and harvested at four different circadian stages were incubated for 2 hours with 0.4 IU synthetic ACTH in 2 ml Krebs-Ringer buffer (KR), or with 50, 150, and 450 microM of melatonin in KR containing 0.4 IU ACTH. The addition of melatonin to ACTH leads to a dose dependent stimulation of production and/or secretion of DHEA into the incubation medium irrespective of the circadian stage of harvesting of the adrenals. This relationship is of interest in view of the simultaneous decrease of dehydroepiandrosterone and melatonin in the course of aging, and the effects of these compounds upon aging related changes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Deshidroepiandrosterona
/
Glándulas Suprarrenales
/
Melatonina
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos