Role of lipids in development of noninsulin-dependent diabetes mellitus: lessons learned from Pima Indians.
Lipids
; 31 Suppl: S267-70, 1996 Mar.
Article
en En
| MEDLINE
| ID: mdl-8729131
ABSTRACT
We studied the role of lipids in the pathogenesis of noninsulin-dependent diabetes mellitus (NIDDM) in Pima Indians. High plasma levels of nonesterified fatty acid (NEFA) predicted development of NIDDM, but this effect cannot entirely be explained by the glucose-fatty acid cycle. Dyslipidemia, although often associated with diabetes, did not seem to predict NIDDM and might rather be associated with, or the consequence of insulin resistance. In some individuals, a single amino acid substitution in the intestinal fatty acid binding protein could result in increased rates of intestinal absorption of dietary NEFA and thereby contribute to increased lipid-oxidation rates and insulin resistance.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Indígenas Norteamericanos
/
Proteínas Supresoras de Tumor
/
Diabetes Mellitus Tipo 2
/
Lípidos
/
Proteínas de Neoplasias
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Lipids
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos