Release of vasoactive agents from the isolated perfused human ovary.
Eur J Obstet Gynecol Reprod Biol
; 67(2): 191-6, 1996 Aug.
Article
en En
| MEDLINE
| ID: mdl-8841811
ABSTRACT
OBJECTIVE:
To investigate local vascular control in the isolated perfused premenopausal human ovary by measuring flow-induced release of vasoactive substances.DESIGN:
Release of adenosine 5' triphosphate (ATP), substance P (SP), endothelin (ET), and vasopressin (AVP) from the ovarian vascular endothelium was estimated in perfusate under basal conditions and during two periods of increased flow. MAIN OUTCOMEMEASURES:
Vascular resistance; ATP, SP, ET and AVP release.RESULTS:
The mean ratio (pressure/flow during increased flow)(pressure/flow at basal flow) was 1.27 +/- 0.04 for the first, and 1.15 +/- 0.05 for the second period of increased flow (n = 10), indicating significant vasoconstriction (P < 0.01 and 0.05, respectively), present to a greater extent during the first period of increased flow compared to the second (P < 0.05). ATP release was seen in response to increased flow (n = 8, P < 0.05). From 12 ovarian bed preparations, five released ET and SP and three of these released AVP. Four of the five perfused ovaries that released peptides contained either a developing follicle or a corpus luteum while all those that showed no peptide release were inactive.CONCLUSIONS:
ATP release may play a role in the local control of the human premenopausal ovarian vasculature independent of ovulatory status. Peptides may also contribute to local vascular control in the ovary and their release from predominantly active ovaries suggests a relationship between ovulation and vascular endothelial function.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ovario
/
Vasoconstrictores
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Reino Unido