Design of novel cholecystokinin-B receptor ligands based on the 'double-ring system' approach.
Regul Pept
; 65(1): 11-4, 1996 Aug 27.
Article
en En
| MEDLINE
| ID: mdl-8876030
ABSTRACT
A structurally novel series of cholecystokinin-B (CCK-B) receptor ligands has been designed and synthesized based on the 'double ring system' theory of receptor recognition. Compounds 2b-cis and 2g-cis from this 1-amino-2-benzyltetralin series show modest CCK-B receptor affinity, with IC50 values of 48.5 nM and 39.0 nM, respectively. The results are discussed in the context of ongoing efforts to identify the CCK-B receptor binding site for nonpeptide ligands.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Colecistoquinina
Idioma:
En
Revista:
Regul Pept
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos