Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA.
Cancer Res
; 57(3): 366-9, 1997 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-9012456
ABSTRACT
The nitrosated bile acid conjugate N-nitrosoglycocholic acid reacts with DNA to give, rise to several adducts including O6-carboxymethylguanine and, unexpectedly, O6-methylguanine (O6-MG). O6-MG is well established as a toxic and promutagenic lesion and is a substrate for the DNA repair protein O6-alkylguanine-DNA-alkyltransferase. In contrast, O6-carboxymethylguanine is not repaired by this protein. Similar results have been obtained for other nitrosated glycine derivatives, which suggests that O6-MG, which has been observed in DNA from human gastrointestinal tissues, may be derived from intragastric nitrosation of glycine or related compounds.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ADN
/
Glicina
/
Guanina
/
Nitrosaminas
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
1997
Tipo del documento:
Article
País de afiliación:
Reino Unido