A structural model for 30 Rh D epitopes based on serological and DNA sequence data from partial D phenotypes.
Transfus Clin Biol
; 3(6): 391-6, 1996.
Article
en En
| MEDLINE
| ID: mdl-9018796
ABSTRACT
Both cDNA RHD sequences and reactivity with monoclonal anti-D have been reported in a number of partial D phenotypes, where parts (some epitopes) of the normal D antigen are missing, and anti-D of restricted specificity may be made in response to challenge with normal D positive blood. This paper analyses these reports together and proposes a model for the structure which comprise the epitopes of the Rh D antigen. Some epitopes are proposed to be comprised of continuous peptide sequence within one extracellular loop, whereas others require interactions between two or the extracellular peptide loops.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sistema del Grupo Sanguíneo Rh-Hr
/
Estructura Terciaria de Proteína
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Transfus Clin Biol
Asunto de la revista:
HEMATOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Reino Unido