[Immunogenic activity of cultural antirabies vaccine inactivated by gamma-rays]. / Immunogennaia aktivnost' kul'tural'noi antirabicheskoi vaktsiny, inaktivirovannoi gamma-luchami.

ABSTRACT

Experimental lyophilized tissue culture rabies vaccine inactivated with gamma-rays was prepared from the Vnukovo-32 strain and showed a sufficiently high immunogenic activity. Complete inactivation of the virus and the immunogenic potency of the vaccine depended upon the dose of irradiation and temperature during irradiation. The virus lost infectivity at 18 degrees C when irradiated with 2.6 X 10(6) r and at --70 degrees C with 4.55 X 10(6) r. However, the immunogenic potency of the vaccine inactivated at minus temperature without thawing was significantly higher.